Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1143)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0348492	0.0998208	0.7304771
Weighted median	23	0.0096246	0.0539336	0.8583679
Inverse variance weighted	23	-0.0147177	0.0390159	0.7060076
Simple mode	23	0.0612601	0.0848624	0.4779737
Weighted mode	23	0.0300633	0.0628440	0.6370990

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.19559	21	0.8610522
Inverse variance weighted	14.24360	22	0.8926085

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012363	0.0056423	0.8286826

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004359	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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