Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1142)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0568762	0.0998202	0.5748677
Weighted median	23	0.0613968	0.0541087	0.2565033
Inverse variance weighted	23	0.0443331	0.0390155	0.2558332
Simple mode	23	-0.0626498	0.0935123	0.5098532
Weighted mode	23	0.0682920	0.0672935	0.3212146

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.31489	21	0.8971945
Inverse variance weighted	13.33353	22	0.9234399

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007703	0.0056423	0.8927126

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004432	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8