Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1141)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0259119	0.1153322	0.8244061
Weighted median	23	0.0557723	0.0574434	0.3315935
Inverse variance weighted	23	0.0404620	0.0444501	0.3626754
Simple mode	23	0.0603827	0.0952801	0.5327853
Weighted mode	23	0.0334754	0.0693658	0.6341523

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.03403	21	0.1391888
Inverse variance weighted	28.55590	22	0.1579821

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004076	0.0065191	0.5385497

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008978	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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