Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1140)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0409214	0.0998206	0.6859950
Weighted median	23	-0.0485576	0.0538417	0.3671319
Inverse variance weighted	23	0.0308081	0.0390156	0.4297408
Simple mode	23	-0.0182221	0.0919772	0.8447741
Weighted mode	23	-0.0393658	0.0602850	0.5205252

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.17663	21	0.5738107
Inverse variance weighted	19.78610	22	0.5964179

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044049	0.0056423	0.4436989

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006185	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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