Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 114)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1524643	0.1173826	0.2080712
Weighted median	23	0.0102920	0.0563416	0.8550560
Inverse variance weighted	23	-0.0486713	0.0483825	0.3144311
Simple mode	23	-0.1362005	0.1154490	0.2507016
Weighted mode	23	0.0157526	0.0624602	0.8032263

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.03948	21	0.1130569
Inverse variance weighted	33.83172	22	0.0510933

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0123516	0.006635	0.0767166

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010723	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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