Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1139)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0840838	0.1057855	0.4355918
Weighted median	23	-0.0346480	0.0595498	0.5606791
Inverse variance weighted	23	0.0160348	0.0408637	0.6947651
Simple mode	23	0.1451670	0.1198047	0.2384827
Weighted mode	23	-0.0366021	0.0981655	0.7128198

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.58570	21	0.3135621
Inverse variance weighted	24.13426	22	0.3402314

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041789	0.0059796	0.4923029

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007364	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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