Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1138)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0044957	0.0998213	0.9645032
Weighted median	23	-0.0148014	0.0542020	0.7847932
Inverse variance weighted	23	-0.0076960	0.0390159	0.8436300
Simple mode	23	0.0688535	0.0840749	0.4215960
Weighted mode	23	-0.0236672	0.0637349	0.7139374

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.59944	21	0.9498060
Inverse variance weighted	11.61704	22	0.9647914

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007487	0.0056424	0.8957017

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003532	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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