Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1137)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0599847	0.0998203	0.5543203
Weighted median	23	0.0484729	0.0540627	0.3699297
Inverse variance weighted	23	0.0583107	0.0390154	0.1350304
Simple mode	23	-0.0329477	0.0859335	0.7050964
Weighted mode	23	0.0580739	0.0636764	0.3716459

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.59985	21	0.8861661
Inverse variance weighted	13.60019	22	0.9150601

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001028	0.0056424	0.9856362

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004798	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8