Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1136)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1663602	0.1009459	0.1142320
Weighted median	23	-0.0087635	0.0583516	0.8806186
Inverse variance weighted	23	0.0225677	0.0406871	0.5791249
Simple mode	23	0.0210130	0.0993982	0.8345198
Weighted mode	23	0.0210130	0.0793188	0.7935391

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.47642	21	0.4301991
Inverse variance weighted	23.92569	22	0.3511368

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0088303	0.0057059	0.1366676

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007352	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8