Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1135)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0184251	0.1112034	0.8699872
Weighted median	23	-0.0683046	0.0629386	0.2778076
Inverse variance weighted	23	-0.0116800	0.0425529	0.7837142
Simple mode	23	-0.0937361	0.1136233	0.4182430
Weighted mode	23	-0.1400852	0.1002546	0.1762595

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.06350	21	0.2040381
Inverse variance weighted	26.17087	22	0.2444183

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018488	0.0062858	0.7715554

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007957	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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