Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1134)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0301174	0.0998202	0.7658359
Weighted median	23	-0.0149392	0.0561961	0.7903621
Inverse variance weighted	23	0.0101101	0.0390155	0.7955341
Simple mode	23	-0.0852589	0.0896709	0.3520368
Weighted mode	23	-0.0498249	0.0632286	0.4390986

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.90558	21	0.4647232
Inverse variance weighted	21.09728	22	0.5147333

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024704	0.0056423	0.6659806

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006413	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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