Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1133)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0274723	0.1094352	0.8042254
Weighted median	23	0.0731780	0.0627582	0.2436024
Inverse variance weighted	23	0.0370343	0.0417995	0.3756188
Simple mode	23	0.1682146	0.1266718	0.1978067
Weighted mode	23	0.1896948	0.1019767	0.0762823

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.24162	21	0.2368509
Inverse variance weighted	25.25245	22	0.2851550

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005872	0.0061859	0.9252727

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007925	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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