Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1132)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0611373	0.1219055	0.6212268
Weighted median	23	-0.0951912	0.0614338	0.1212630
Inverse variance weighted	23	-0.0059292	0.0468198	0.8992260
Simple mode	23	-0.0590277	0.1124526	0.6048942
Weighted mode	23	-0.1114729	0.0749488	0.1511233

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.32082	21	0.0684819
Inverse variance weighted	31.68188	22	0.0829838

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033903	0.0068907	0.6278127

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009607	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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