Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1131)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2988454	0.1258352	0.0271591
Weighted median	23	0.0164584	0.0622526	0.7914863
Inverse variance weighted	23	0.0137321	0.0545468	0.8012350
Simple mode	23	-0.0231972	0.0901351	0.7992924
Weighted mode	23	0.0005364	0.0789978	0.9946433

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.37402	21	0.0422309
Inverse variance weighted	43.00384	22	0.0047140

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0175088	0.0071128	0.0225712

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013067	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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