Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1130)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1568194	0.1057876	0.1530865
Weighted median	23	-0.0266076	0.0540565	0.6225657
Inverse variance weighted	23	-0.0160801	0.0423592	0.7042337
Simple mode	23	0.0655905	0.0825403	0.4353072
Weighted mode	23	-0.0112692	0.0543055	0.8375162

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.58595	21	0.3135496
Inverse variance weighted	25.93231	22	0.2545997

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086427	0.0059796	0.1631116

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000791	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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