Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 113)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2422907	0.0998201	0.0242933
Weighted median	23	-0.0325196	0.0564327	0.5644429
Inverse variance weighted	23	0.0476672	0.0457703	0.2976696
Simple mode	23	-0.0218181	0.0893028	0.8092506
Weighted mode	23	-0.0354595	0.0597149	0.5586941

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.31791	21	0.5012118
Inverse variance weighted	30.27730	22	0.1118789

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0178062	0.0056423	0.004767

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009626	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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