Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1129)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1914054	0.0998204	0.0688781
Weighted median	23	0.0370584	0.0558705	0.5071446
Inverse variance weighted	23	0.0272677	0.0407223	0.5031126
Simple mode	23	-0.0432621	0.0906365	0.6378457
Weighted mode	23	0.0355442	0.0663768	0.5976826

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.77565	21	0.4727168
Inverse variance weighted	23.96701	22	0.3489610

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0100797	0.0056423	0.0884754

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007411	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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