Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1128)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0750262	0.1136874	0.5164691
Weighted median	23	-0.0149157	0.0572517	0.7944560
Inverse variance weighted	23	0.0062455	0.0438583	0.8867631
Simple mode	23	-0.0208776	0.1143863	0.8568477
Weighted mode	23	-0.0082851	0.0809381	0.9193955

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.24075	21	0.1630258
Inverse variance weighted	27.80116	22	0.1823648

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042238	0.0064262	0.518137

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008432	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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