Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1127)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0216812	0.0998209	0.8301480
Weighted median	23	-0.0453739	0.0583803	0.4370333
Inverse variance weighted	23	-0.0341817	0.0390158	0.3809766
Simple mode	23	-0.0426845	0.0957868	0.6602264
Weighted mode	23	-0.0357077	0.0723048	0.6263072

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.09463	21	0.7053540
Inverse variance weighted	17.11314	22	0.7570864

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007677	0.0056424	0.8930759

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005418	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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