Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1126)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0198669	0.0998211	0.8441578
Weighted median	23	0.0251705	0.0557099	0.6514032
Inverse variance weighted	23	0.0015297	0.0390159	0.9687246
Simple mode	23	0.0555265	0.0902272	0.5445998
Weighted mode	23	0.0344311	0.0682758	0.6190677

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.72573	21	0.9179264
Inverse variance weighted	12.76556	22	0.9394939

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011261	0.0056424	0.8437321

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003869	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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