Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1125)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1286005	0.1014465	0.2187926
Weighted median	23	0.1060327	0.0644672	0.1000203
Inverse variance weighted	23	0.0668627	0.0391409	0.0875886
Simple mode	23	0.0750071	0.1119307	0.5097546
Weighted mode	23	0.1308938	0.0856674	0.1407807

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.69042	21	0.4175338
Inverse variance weighted	22.14194	22	0.4514442

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037913	0.0057343	0.5156914

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00076	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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