Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1124)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1857373	0.1273351	0.1594572
Weighted median	23	-0.0521958	0.0681416	0.4436816
Inverse variance weighted	23	-0.0463588	0.0502361	0.3561020
Simple mode	23	0.1690056	0.1411488	0.2439097
Weighted mode	23	0.0366747	0.1041735	0.7281476

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.17397	21	0.0347151
Inverse variance weighted	36.47525	22	0.0269879

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085593	0.0071977	0.2476425

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001148	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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