Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1123)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0083586	0.1112371	0.9408128
Weighted median	23	0.0308504	0.0581382	0.5956683
Inverse variance weighted	23	-0.0013365	0.0424829	0.9749023
Simple mode	23	0.1193820	0.0933694	0.2143630
Weighted mode	23	0.0620990	0.0623999	0.3304703

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.07820	21	0.2034829
Inverse variance weighted	26.08404	22	0.2480911

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004312	0.0062877	0.9459707

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007904	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8