Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1122)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0307182	0.0998211	0.7613169
Weighted median	23	-0.0028857	0.0538753	0.9572841
Inverse variance weighted	23	0.0195488	0.0390158	0.6163361
Simple mode	23	-0.0312694	0.0854959	0.7180515
Weighted mode	23	-0.0155795	0.0645457	0.8115027

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.66457	21	0.6701208
Inverse variance weighted	17.96388	22	0.7081276

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030869	0.0056424	0.5900827

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005519	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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