Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1121)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1013912	0.1031321	0.3367403
Weighted median	23	-0.0032531	0.0543076	0.9522339
Inverse variance weighted	23	0.0266606	0.0399603	0.5046586
Simple mode	23	-0.0035657	0.0914932	0.9692637
Weighted mode	23	-0.0035657	0.0792891	0.9645359

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.41662	21	0.3758521
Inverse variance weighted	23.07817	22	0.3973269

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045892	0.0058295	0.4399395

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007135	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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