Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1120)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1501893	0.1028866	0.1591557
Weighted median	23	0.0849186	0.0556682	0.1271490
Inverse variance weighted	23	0.1039527	0.0395119	0.0085154
Simple mode	23	0.0810315	0.0908982	0.3823324
Weighted mode	23	0.0941764	0.0678425	0.1789861

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.31071	21	0.3817985
Inverse variance weighted	22.56396	22	0.4266900

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028394	0.0058157	0.6304439

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008988	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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