Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 112)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2271845	0.0998203	0.0334428
Weighted median	23	-0.0938730	0.0557316	0.0921092
Inverse variance weighted	23	-0.0308879	0.0390155	0.4285454
Simple mode	23	-0.0782867	0.0929062	0.4084969
Weighted mode	23	-0.0962994	0.0583234	0.1129166

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.78911	21	0.9158307
Inverse variance weighted	17.35353	22	0.7435557

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0120546	0.0056423	0.0445729

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005449	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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