Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1119)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0512112	0.1157534	0.6627110
Weighted median	23	0.0290014	0.0589605	0.6228053
Inverse variance weighted	23	0.0466660	0.0450821	0.3006069
Simple mode	23	0.0305113	0.0995462	0.7621035
Weighted mode	23	0.0175023	0.0659434	0.7931616

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.23867	21	0.1335112
Inverse variance weighted	29.37347	22	0.1345039

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060106	0.0065429	0.3687141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009334	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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