Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1118)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0069881	0.1305562	0.9578192
Weighted median	23	0.0665572	0.0585748	0.2558408
Inverse variance weighted	23	0.0530708	0.0501510	0.2899542
Simple mode	23	0.0957673	0.0940276	0.3195097
Weighted mode	23	0.0847828	0.0657810	0.2108339

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.92356	21	0.0223014
Inverse variance weighted	36.35085	22	0.0278377

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036882	0.0073797	0.6224265

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011575	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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