Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1117)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0540559	0.1095473	0.6268172
Weighted median	23	0.0034225	0.0573835	0.9524400
Inverse variance weighted	23	0.0128046	0.0422686	0.7619394
Simple mode	23	0.0810837	0.0935998	0.3956863
Weighted mode	23	0.0170260	0.0668141	0.8012245

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.29183	21	0.2347460
Inverse variance weighted	25.82137	22	0.2594306

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041059	0.0061921	0.5144911

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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