Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1116)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0998477	0.0998206	0.3285663
Weighted median	23	0.0595808	0.0553138	0.2814173
Inverse variance weighted	23	0.0084918	0.0390156	0.8277009
Simple mode	23	0.0525606	0.0838014	0.5369809
Weighted mode	23	0.0648109	0.0601796	0.2931674

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.68669	21	0.9192009
Inverse variance weighted	13.67532	22	0.9126010

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056101	0.0056423	0.3313983

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004158	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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