Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1115)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0372117	0.0998200	0.7130420
Weighted median	23	0.0482452	0.0573122	0.3999020
Inverse variance weighted	23	-0.0167622	0.0390154	0.6674650
Simple mode	23	0.0220662	0.0873065	0.8028124
Weighted mode	23	0.0459889	0.0632830	0.4750608

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.09192	21	0.5154455
Inverse variance weighted	20.43701	22	0.5557239

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033145	0.0056423	0.5631701

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006249	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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