Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1114)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0605736	0.1018776	0.5584816
Weighted median	23	-0.0338219	0.0529018	0.5226064
Inverse variance weighted	23	-0.0503304	0.0390154	0.1970463
Simple mode	23	0.0116982	0.0888866	0.8964908
Weighted mode	23	-0.0080151	0.0631997	0.9002334

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.87451	21	0.4067722
Inverse variance weighted	21.88694	22	0.4666543

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000629	0.0057586	0.914054

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007136	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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