Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1113)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0924988	0.1128052	0.4214333
Weighted median	23	-0.1225909	0.0581501	0.0350156
Inverse variance weighted	23	-0.0688924	0.0431302	0.1101958
Simple mode	23	-0.1140017	0.0957461	0.2464736
Weighted mode	23	-0.1252179	0.0672219	0.0759045

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.82004	21	0.1768895
Inverse variance weighted	26.88606	22	0.2155862

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014497	0.0063764	0.8223479

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009092	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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