Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1112)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0489037	0.0998204	0.6292720
Weighted median	23	0.0224134	0.0571693	0.6950185
Inverse variance weighted	23	0.0077298	0.0390155	0.8429498
Simple mode	23	0.0466451	0.0987043	0.6411714
Weighted mode	23	0.0352806	0.0745081	0.6405122

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.21632	21	0.5075990
Inverse variance weighted	20.59625	22	0.5457958

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034779	0.0056423	0.544264

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006253	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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