Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1111)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1570295	0.1084552	0.1624183
Weighted median	23	-0.1149691	0.0559203	0.0397879
Inverse variance weighted	23	-0.0941484	0.0418057	0.0243194
Simple mode	23	-0.0325370	0.1084739	0.7670292
Weighted mode	23	-0.1165688	0.0680755	0.1008944

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.79120	21	0.2563204
Inverse variance weighted	25.25961	22	0.2848219

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038616	0.0061305	0.5355559

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009419	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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