Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1110)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0044388	0.1173608	0.9701872
Weighted median	23	-0.0357463	0.0607712	0.5563902
Inverse variance weighted	23	-0.0244215	0.0448931	0.5864472
Simple mode	23	-0.0744676	0.1167103	0.5300243
Weighted mode	23	-0.0633068	0.0842524	0.4603785

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.02976	21	0.1132890
Inverse variance weighted	29.12842	22	0.1412306

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017723	0.0066339	0.7919499

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008945	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8