Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 111)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1610980	0.0998205	0.1214810
Weighted median	23	0.0366314	0.0558704	0.5120505
Inverse variance weighted	23	0.0029662	0.0390155	0.9393988
Simple mode	23	-0.0635524	0.0821447	0.4473633
Weighted mode	23	0.0282667	0.0623502	0.6547334

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.78647	21	0.5988358
Inverse variance weighted	21.74855	22	0.4749802

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0097108	0.0056423	0.0999395

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006592	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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