Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1109)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0796506	0.0998209	0.4338390
Weighted median	23	0.0046207	0.0542957	0.9321798
Inverse variance weighted	23	0.0057445	0.0390160	0.8829462
Simple mode	23	0.0562432	0.0887154	0.5326352
Weighted mode	23	0.0032064	0.0613510	0.9587903

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.27656	21	0.9571266
Inverse variance weighted	11.92358	22	0.9589372

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045386	0.0056424	0.4301932

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000362	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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