Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1108)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0812528	0.1020229	0.4347012
Weighted median	23	0.0558120	0.0540181	0.3015061
Inverse variance weighted	23	0.0289539	0.0392463	0.4606671
Simple mode	23	0.0072072	0.0957894	0.9407041
Weighted mode	23	0.0570137	0.0584152	0.3396717

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.93701	21	0.4031475
Inverse variance weighted	22.26101	22	0.4444049

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0032117	0.0057668	0.5834684

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006912	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8