Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1107)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0672309	0.0998213	0.5079665
Weighted median	23	0.0121158	0.0575134	0.8331529
Inverse variance weighted	23	0.0750192	0.0390158	0.0545062
Simple mode	23	0.0462523	0.0911482	0.6168952
Weighted mode	23	0.0068844	0.0678489	0.9200989

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.307795	21	0.9865782
Inverse variance weighted	11.704735	22	0.9631805

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0087355	0.0056424	0.136512

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004667	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8