Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1106)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.2257082 0.0998198 0.0344882
Weighted median 23 0.0253105 0.0564099 0.6536565
Inverse variance weighted 23 0.0423925 0.0403436 0.2933574
Simple mode 23 -0.0084163 0.0999412 0.9336487
Weighted mode 23 0.0366226 0.0626674 0.5648990

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 19.54253 21 0.5503798
Inverse variance weighted 23.52328 22 0.3727042

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0112574 0.0056423 0.0591605

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007485 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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