Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1105)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1351928	0.1227686	0.2832720
Weighted median	23	-0.0500707	0.0557507	0.3691232
Inverse variance weighted	23	0.0062772	0.0486000	0.8972314
Simple mode	23	0.0469399	0.0907345	0.6100864
Weighted mode	23	-0.0434175	0.0564066	0.4496497

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.76594	21	0.0618214
Inverse variance weighted	34.13675	22	0.0475737

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086876	0.0069394	0.2243643

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010352	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8