Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1104)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0325390	0.1276799	0.8013193
Weighted median	23	-0.0082789	0.0535577	0.8771537
Inverse variance weighted	23	0.0147804	0.0487836	0.7619065
Simple mode	23	-0.0349898	0.0902809	0.7020616
Weighted mode	23	-0.0205795	0.0621705	0.7437633

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.35786	21	0.0331667
Inverse variance weighted	34.39522	22	0.0447603

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010905	0.007217	0.881333

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010465	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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