Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1103)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1591566	0.1307738	0.2370911
Weighted median	23	0.0015379	0.0629712	0.9805160
Inverse variance weighted	23	0.0286143	0.0513185	0.5771296
Simple mode	23	0.0529476	0.1131926	0.6445528
Weighted mode	23	0.0003417	0.0737733	0.9963457

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.04456	21	0.0216146
Inverse variance weighted	38.06330	22	0.0180245

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0080166	0.007392	0.2904367

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011697	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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