Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1102)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1461779	0.1382983	0.3025310
Weighted median	23	-0.0525563	0.0609954	0.3888839
Inverse variance weighted	23	-0.0332617	0.0537921	0.5363527
Simple mode	23	-0.0515891	0.0900643	0.5725864
Weighted mode	23	-0.0475800	0.0649268	0.4714016

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.31075	21	0.0068155
Inverse variance weighted	41.82110	22	0.0065701

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069342	0.0078173	0.3851092

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012891	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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