Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1101)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2561256	0.1169145	0.0398948
Weighted median	23	-0.0485612	0.0609386	0.4255166
Inverse variance weighted	23	-0.0449694	0.0485669	0.3544834
Simple mode	23	-0.0214282	0.1108320	0.8484669
Weighted mode	23	-0.0995153	0.0620556	0.1230529

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.80914	21	0.1186596
Inverse variance weighted	34.09093	22	0.0480884

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0129672	0.0066086	0.0631316

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010732	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8