Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1100)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0468749	0.0998212	0.6434883
Weighted median	23	0.0025839	0.0521982	0.9605197
Inverse variance weighted	23	-0.0201424	0.0390157	0.6056697
Simple mode	23	0.0291866	0.0922772	0.7547617
Weighted mode	23	0.0188784	0.0621898	0.7643150

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.05954	21	0.6452333
Inverse variance weighted	18.59156	22	0.6703957

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041155	0.0056424	0.4738174

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005714	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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