Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 110)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0123971	0.1155605	0.9155870
Weighted median	23	-0.0042506	0.0575488	0.9411218
Inverse variance weighted	23	-0.0049691	0.0441573	0.9104014
Simple mode	23	0.0309275	0.0906533	0.7362184
Weighted mode	23	-0.0019986	0.0707266	0.9777106

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.14505	21	0.1360852
Inverse variance weighted	28.18078	22	0.1697672

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010665	0.006532	0.8718705

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008544	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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