Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 11)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0254019	0.0998207	0.8016037
Weighted median	23	0.0345185	0.0571826	0.5460741
Inverse variance weighted	23	0.0423362	0.0390155	0.2778718
Simple mode	23	0.0645444	0.0952372	0.5050134
Weighted mode	23	0.0265380	0.0729077	0.7193370

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.35902	21	0.7491520
Inverse variance weighted	16.39299	22	0.7959145

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010399	0.0056423	0.8555395

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005324	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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